Bis(4-hydroxyphenyl)methane → HCID 20510578、化合物

HRID 1758203ノート

反応式

HRID 1758203 の反応式
[CH2:1]([N:5]1[C:9](=[O:10])[C:8]2([CH2:15][C:14]([CH3:17])([CH3:16])[N:13]([CH2:18][CH:19]3[O:21][CH2:20]3)[C:12]([CH3:23])([CH3:22])[CH2:11]2)[NH:7][C:6]1=[O:24])[CH2:2][CH2:3][CH3:4].[OH:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([OH:39])=[CH:35][CH:34]=2)=[CH:28][CH:27]=1.[H-].[Na+]>C(O)CC(C)C>[CH2:1]([N:5]1[C:9](=[O:10])[C:8]2([CH2:11][C:12]([CH3:22])([CH3:23])[N:13]([CH2:18][CH:19]([OH:21])[CH2:20][O:25][C:26]3[CH:27]=[CH:28][C:29]([CH2:32][C:33]4[CH:38]=[CH:37][C:36]([O:39][CH2:20][CH:19]([OH:21])[CH2:18][N:13]5[C:14]([CH3:17])([CH3:16])[CH2:15][C:8]6([NH:7][C:6](=[O:24])[N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[C:9]6=[O:10])[CH2:11][C:12]5([CH3:22])[CH3:23])=[CH:35][CH:34]=4)=[CH:30][CH:31]=3)[C:14]([CH3:17])([CH3:16])[CH2:15]2)[NH:7][C:6]1=[O:24])[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 3

HCID 12111Bis(4-hydroxyphenyl)methaneHCID 24758Sodium hydrideHCID 20510596HCID 20510596、化合物

生成物 1

HCID 20510578HCID 20510578、化合物

試薬・触媒・溶媒 1

HCID 31260Isoamyl Alcohol溶媒

実験手順

A mixture of 4.0 g of 3-butyl-8-(2,3-epoxypropyl)-7,7,9,9-tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione and 1.0 g of bis(p-hydroxyphenyl)methane in 5 ml of isopentyl alcohol with a catalytic amount of sodium hydride was refluxed for 10 hours. After completion of the reaction, the residue obtained by evaporating the solvent under reduced pressure from the reaction mixture was purified by column chromatography through silica gel eluted with a 1:1 by volume mixture of benzene and ethyl acetate, giving the desired Compound No. 351 in the form of white crystals melting at 202°-204° C.

後処理

  1. temperaturewas refluxed for 10 hours
  2. customAfter completion of the reaction
  3. customthe residue obtained
  4. customby evaporating the solvent under reduced pressure from the reaction mixture
  5. customwas purified by column chromatography through silica gel
  6. washeluted with a 1:1 by volume mixture of benzene and ethyl acetate

出典と根拠

ORDレコード
ord-ede89440b52340ad8bbc0763d430f07c
出典データセット
uspto-grants-1983_02
特許番号
US04371644

反応ノート

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