Thionyl Chloride → alpha-Chloro-5-methyl-2-nitrotoluene

HRID 1758232ノート

反応式

HRID 1758232 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH:9]=1)[CH2:7]O.S(Cl)([Cl:15])=O>C1C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH:9]=1)[CH2:7][Cl:15]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 568847(5-Methyl-2-nitrophenyl)methanol

生成物 1

HCID 2724031alpha-Chloro-5-methyl-2-nitrotoluene

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

The above reaction product obtained in step (a) is mixed with 600 ml of benzene and 60 ml of thionyl chloride, and left to stand for 18 hours at room temperature. The reaction solution is concentrated and subsequently partitioned between benzene and ice-water. After the organic phase is washed, dried and evaporated, the heading compound remains as an orange, semi-crystalline crude product, which is used in step (c) without further purification.

後処理

  1. waitleft
  2. concentrationThe reaction solution is concentrated
  3. customsubsequently partitioned between benzene and ice-water
  4. washAfter the organic phase is washed
  5. customdried
  6. customevaporated
  7. customis used in step (c) without further purification

出典と根拠

ORDレコード
ord-dafb066447b244b1a73620f05b30c1e3
出典データセット
uspto-grants-1983_02
特許番号
US04372956

反応ノート

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