Sodium Carbonate → HCID 14099940、化合物

HRID 1758445ノート

反応式

HRID 1758445 の反応式
Cl.Cl[CH:3]([C:17]1[CH:18]=[CH:19][C:20]([CH3:27])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH2:4][NH:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH3:16].C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)(=O)C>[CH3:16][O:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH2:6][N:5]1[CH2:4][CH:3]1[C:17]1[CH:18]=[CH:19][C:20]([CH3:27])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 131062635-{1-Chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride

生成物 1

HCID 14099940HCID 14099940、化合物収率 88.3%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

In 50 ml of ethyl acetate was suspended 4.35 g (0.01 mole) of 5-{1-chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride and then 50 ml of an aqueous 10% sodium carbonate solution was added to the suspension with stirring. After further stirring overnight vigorously, the reaction mixture was recovered by decantation. After removing inorganic matters by passing the ethyl acetate layer thus recovered through a silica gel column (50 ml of silica gel), the reaction product was evaporated to dryness to provide 3.2 g (88%) of colorless resinous 5-{1-[2-(2-methoxyphenoxy)-ethyl]aziridin-2-yl}-2-methylbenzenesulfonamide

後処理

  1. stirringAfter further stirring overnight vigorously
  2. customthe reaction mixture was recovered by decantation
  3. customAfter removing inorganic matters
  4. customthus recovered through a silica gel column (50 ml of silica gel)
  5. customthe reaction product was evaporated to dryness

出典と根拠

ORDレコード
ord-4e0a794a87334e8eae8221d7b1490cde
出典データセット
uspto-grants-1983_02
特許番号
US04373106

反応ノート

読み込み中…