Sodium Hydroxide → 7-[3-[4-(3-Phenylthio-propyl)-1-piperazinyl]-propyl]-theophylline

HRID 1758703

反応式

HRID 1758703 の反応式
Cl[CH2:2][CH2:3][CH2:4][N:5]1[C:14]2[C:13](=[O:15])[N:11]([CH3:12])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=2[N:7]=[CH:6]1.[C:18]1([S:24][CH2:25][CH2:26][CH2:27][N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[OH-].[Na+]>>[C:18]1([S:24][CH2:25][CH2:26][CH2:27][N:28]2[CH2:33][CH2:32][N:31]([CH2:2][CH2:3][CH2:4][N:5]3[C:14]4[C:13](=[O:15])[N:11]([CH3:12])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=4[N:7]=[CH:6]3)[CH2:30][CH2:29]2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

参加物

4

反応物 3

HCID 14798Sodium HydroxideHCID 760117-(3-Chloropropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dioneHCID 21954921-(3-(Phenylthio)propyl)piperazine

生成物 1

HCID 30617397-[3-[4-(3-Phenylthio-propyl)-1-piperazinyl]-propyl]-theophylline

実験手順

7-(3-Chloropropyl)-theophylline (1 mole) and 1-(3-phenylthiopropyl)-piperazine are refluxed for 24 hours in a 50% aqueous-alcoholic solution. On completion of the reaction, sodium hydroxide (1 mole) is then added. The mixture is extracted with methylene chloride and washed with water, after which the solvent is evaporated off and the residue is recrystallized from ethanol.

後処理

  1. additionis then added
  2. extractionThe mixture is extracted with methylene chloride
  3. washwashed with water
  4. customafter which the solvent is evaporated off
  5. customthe residue is recrystallized from ethanol

出典と根拠

ORDレコード
ord-ff943f179a204bf99252551d0e6d29af
出典データセット
uspto-grants-1983_02
特許番号
US04374835

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