Formaldehyde → HCID 20531688、化合物

HRID 1759319ノート

反応式

HRID 1759319 の反応式
[CH3:1][O:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][NH:6][CH2:7][CH:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH3:19])[CH:11]=1)[OH:9].[CH2:24]=O>C(O)=O>[CH3:1][O:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][N:6]([CH3:24])[CH2:7][CH:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH3:19])[CH:11]=1)[OH:9]

参加物

4

反応物 2

HCID 712FormaldehydeHCID 20531701HCID 20531701、化合物

生成物 1

HCID 20531688HCID 20531688、化合物収率 93%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

A mixture of 1.85 g. (0.0058 m) of N-(2-methoxybenzyl)-1-(3,4-dimethoxyphenyl)-2-aminoethanol prepared as in Example 3, 4.8 ml of 90% formic acid and 4.5 ml of 37% formaldehyde was heated in a steam bath for 18 hours. The aqueous portion was evaporated and the residue redissolved in water. After making the solution acid with concentrated hydrochloroic acid, the mixture was heated for 20 minutes, cooled, made basic and extracted with chloroform. The organic extract was washed with water, brine then dried. Evaporation gave 1.8 g (93%) of N-(2-methoxybenzyl)-1-(3,4-dimethoxyphenyl)-N-methyl-2-amino ethanol as an oil.

後処理

  1. additionA mixture of 1.85 g
  2. temperaturewas heated in a steam bath for 18 hours
  3. customThe aqueous portion was evaporated
  4. dissolutionthe residue redissolved in water
  5. concentrationwith concentrated hydrochloroic acid
  6. temperaturethe mixture was heated for 20 minutes
  7. temperaturecooled
  8. extractionextracted with chloroform
  9. extractionThe organic extract
  10. washwas washed with water, brine
  11. customthen dried
  12. customEvaporation

出典と根拠

ORDレコード
ord-17e0ed5a363248feaa1889abfa120db1
出典データセット
uspto-grants-1982_07
特許番号
US04340600

反応ノート

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