Potassium Carbonate → HCID 13023013、化合物
反応式
[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[OH:14])=[CH:6][CH:7]=1.[CH2:15]([CH:17]1[O:19][CH2:18]1)Br.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH:17]2[O:19][CH2:18]2)=[CH:6][CH:7]=1参加物
5
実験手順
A mixture of 3-chloro-6-(2-hydroxyphenyl)pyridazine (2.69 g.), epibromohydrin (4.5 ml.), anhydrous potassium carbonate (3.6 g.) and dry butane-2-one (100 ml.) was stirred and heated under reflux for 16 hours. The mixture was filtered and the filtrate was evaporated to dryness and the residue was twice recrystallized from ethanol to give 3-chloro-6-(2-epoxypropoxyphenyl)pyridazine, m.p. 118°-119°.
後処理
- temperatureheated
- temperatureunder reflux for 16 hours
- filtrationThe mixture was filtered
- customthe filtrate was evaporated to dryness
- customthe residue was twice recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-c7673871e70141e88e1fed2644ed4017
- 出典データセット
- uspto-grants-1982_07
- 特許番号
- US04340733
反応ノート
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