(3R)-3-hydroxy-3-phenylpropanenitrile → (1R)-3-amino-1-phenylpropan-1-ol
反応式
[C:1]1([C@H:7]([OH:11])[CH2:8][C:9]#[N:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C1COCC1>[C:1]1([C@H:7]([OH:11])[CH2:8][CH2:9][NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
3
実験手順
To a THF solution of (R)-3-phenyl-3-hydroxypropanenitrile was slowly added borane dimethyl sulfide complex at room temperature. Methyl sulfide was then distilled from the reaction vessel and the resulting THF solution refluxed for 2.5 h. After cooling to room temperature methanolic HCl was added to the reaction mixture. Methanol and methyl borate were removed by distillation and the reaction mixture neutralized with sodium hydroxide (5N). Extraction of the mixture with dichloromethane followed by concentration provided the crystalline (R)-3-phenyl-3-hydroxypropylamine.
後処理
- customat room temperature
- distillationMethyl sulfide was then distilled from the reaction vessel
- temperaturethe resulting THF solution refluxed for 2.5 h
- additionwas added to the reaction mixture
- customMethanol and methyl borate were removed by distillation
- extractionExtraction of the mixture with dichloromethane
- concentrationfollowed by concentration
出典と根拠
- ORDレコード
- ord-a0ada6ef4b0b43e88a2d67c69f08646f
- 出典データセット
- uspto-grants-2005_01
- 特許番号
- US06838581B2
反応ノート
読み込み中…