Hydrochloric Acid → (1R)-3-amino-1-phenylpropan-1-ol
反応式
[C:1]1([C@H:7]([OH:11])[CH2:8][C:9]#[N:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>C1COCC1>[C:1]1([C@H:7]([OH:11])[CH2:8][CH2:9][NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
To a THF solution of (R)-3-phenyl-3-hydroxypropanenitrile was slowly added borane THF complex at room temperature and then the resulting solution was refluxed for 2.5 h. After cooling to room temperature methanolic HCl was added to the reaction mixture. Methanol and methyl borate were removed by distillation and the reaction mixture neutralized with sodium hydroxide (5N). Extraction of the mixture with dichloromethane,followed by concentration provided the crystalline (R)-3-phenyl-3-hydroxypropylamine.
後処理
- customat room temperature
- temperaturethe resulting solution was refluxed for 2.5 h
- additionwas added to the reaction mixture
- customMethanol and methyl borate were removed by distillation
- extractionExtraction of the mixture with dichloromethane,followed
- concentrationby concentration
出典と根拠
- ORDレコード
- ord-6fd6b3bd1fc44e6494259b36ac039070
- 出典データセット
- uspto-grants-2005_01
- 特許番号
- US06838581B2
反応ノート
読み込み中…