3-Cyclopropyl-3-oxopropanenitrile → Quinoline-2-carbonitrile

HRID 1760337

反応式

HRID 1760337 の反応式
C1(C(=O)CC#[N:7])CC1.[NH2:9][C:10]1[CH:24]=[CH:23][CH:22]=[CH:21][C:11]=1[C:12]([C:14]1C=CC(F)=[CH:16][CH:15]=1)=O>>[N:9]1[C:10]2[C:11](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:12]=[CH:14][C:15]=1[C:16]#[N:7]

参加物

3

反応物 2

HCID 98127633-Cyclopropyl-3-oxopropanenitrileHCID 98372872-Amino-4'-fluorobenzophenone

生成物 1

HCID 74031Quinoline-2-carbonitrile

実験手順

The cyclization reaction step of the present invention is a step of reacting 3-cyclopropyl-3-oxopropanenitrile of the formula (1) with 2-amino-4′-fluorobenzophenone of the formula (2) preferably in the presence of an acid to obtain a quinolinecarbonitrile derivative [2-cyclopropyl-4-(4′-fluorophenyl)quinoline-3-carbonitrile] of the formula (3).

後処理

  1. customThe cyclization reaction step of the present invention

出典と根拠

ORDレコード
ord-fcb79a81fc7d4ba79d80b4b37e899127
出典データセット
uspto-grants-2005_01
特許番号
US06841681B2

関連ノート

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