Sodium Hydroxide → Benzyl D-valinate

HRID 1760774ノート

反応式

HRID 1760774 の反応式
[OH-].[Na+].FC(F)(F)C(O)=O.[CH2:10]([O:17][C:18](=[O:24])[C@@H:19]([CH:21]([CH3:23])[CH3:22])[NH2:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)Cl>[CH2:10]([O:17][C:18](=[O:24])[C@@H:19]([CH:21]([CH3:22])[CH3:23])[NH2:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 69764497d-Valine benzyl ester trifluoroacetic acid salt

生成物 1

HCID 7350007Benzyl D-valinate収率 83%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1 N Sodium hydroxide (80 mL) was added to a solution of D-valine benzyl ester trifluoroacetic acid salt (10 g, 31.1 mmol) in methylene chloride (80 mL) and the reaction mixture was stirred until all the starting material was converted to the free amine. The organic phase was collected and washed with brine, dried over magnesium sulfate, and concentrated to give D-valine benzyl ester (5.35 g) as a clear oil.

後処理

  1. customThe organic phase was collected
  2. washwashed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-e06787d19cec44b5bc528458538a55f9
出典データセット
uspto-grants-2005_01
特許番号
US06844366B2

反応ノート

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