Chlorotrimethylsilane → Methyl 5-cyano-6-methoxypyridine-2-carboxylate

HRID 1761455ノート

反応式

HRID 1761455 の反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:11]([OH:13])=[O:12])=[N:7][C:8]=1[O:9][CH3:10])#[N:2].[CH3:14][Si](C)(C)Cl>CO>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:11]([O:13][CH3:14])=[O:12])=[N:7][C:8]=1[O:9][CH3:10])#[N:2]

参加物

4

反応物 2

HCID 6397ChlorotrimethylsilaneHCID 136501045-Cyano-6-methoxypicolinic acid

生成物 1

HCID 21241774Methyl 5-cyano-6-methoxypyridine-2-carboxylate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-Cyano-6-methoxypyridine-2-carboxylic acid (see above) is reacted in methanol with the help of trimethylchlorosilane to give methyl 5-cyano-6-methoxypyridine-2-carboxylate (m.p. 125°-125° C.). Subsequent hydrogenation in methanol on palladium/charcoal in the presence of hydrochloride acid gives the desired aminomethyl compound (m.p. of the hydrochloride: 224°-226° C.). By the addition of a few drops of triethanolamine, the hydrogenation solution is brought to a pH of 7 and used directly for the following reaction.

出典と根拠

ORDレコード
ord-41281543d4c542d098d966f6504adf37
出典データセット
uspto-grants-1989_05
特許番号
US04826858

反応ノート

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