4-Fluoroaniline → N-[(1-acetyl-4-piperidinyl)methyl]-N'-(4-fluorophenyl)thiourea
反応式
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][N:11]=[C:12]=[S:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[F:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1>O1CCCC1>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][NH:11][C:12]([NH:21][C:18]2[CH:19]=[CH:20][C:15]([F:14])=[CH:16][CH:17]=2)=[S:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]参加物
4
実験手順
A mixture of 4 parts of 1-acetyl-4-(isothiocyanatomethyl)piperidine, 2.2 parts of 4-fluorobenzenamine and 90 parts of tetrahydrofuran was stirred overnight at reflux temperature. The reaction mixture was evaporated, yielding 6.2 parts (100%) of N-[(1-acetyl-4-piperidinyl)methyl]-N'-(4-fluorophenyl)thiourea as a residue (intermediate 12).
後処理
- temperatureat reflux temperature
- customThe reaction mixture was evaporated
出典と根拠
- ORDレコード
- ord-6a1d8895bbe940f8b6de79e2386847b1
- 出典データセット
- uspto-grants-1989_05
- 特許番号
- US04826848
反応ノート
読み込み中…