Methanol → HCID 14500560、化合物

HRID 1761511ノート

反応式

HRID 1761511 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[O:9])=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].CO.[BH4-].[Na+]>C(O)(=O)C>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)[OH:9])=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18]

参加物

5

反応物 3

HCID 887MethanolHCID 3015567(4-Amino-3-nitrophenyl)(4-fluorophenyl)methanoneHCID 4311764Sodium borohydride

生成物 1

HCID 14500560HCID 14500560、化合物収率 99%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a stirred solution of 20 parts of (4-amino-3-nitrophenyl)(4-fluorophenyl)methanone in 120 parts of methanol were added 3.8 parts of sodium tetrahydroborate. The whole was stirred for 30 minutes at room temperature. 12 Parts of acetic acid were added and the mixture was stirred for 15 minutes. After evaporation, water was added to the residue. The product was extracted with 2,2'-oxybispropane. The extract was dried, filtered and evaporated, yielding 20 parts (99%) of 4-amino-α-(4-fluorophenyl)-3-nitrobenzenemethanol as a residue (int. 3).

後処理

  1. stirringthe mixture was stirred for 15 minutes
  2. customAfter evaporation, water
  3. additionwas added to the residue
  4. extractionThe product was extracted with 2,2'-oxybispropane
  5. customThe extract was dried
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-44b28b883bb341a0a639fef30b3b7192
出典データセット
uspto-grants-1989_05
特許番号
US04826862

反応ノート

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