Nitric Acid → N-(5-chloro-4-fluoro-2-nitrophenyl)acetamide

HRID 1761641ノート

反応式

HRID 1761641 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:12])[CH3:11])[CH:5]=[CH:6][C:7]=1[F:8].[N+:13]([O-])([OH:15])=[O:14]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:12])[CH3:11])[C:5]([N+:13]([O-:15])=[O:14])=[CH:6][C:7]=1[F:8]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 589188N-(3-Chloro-4-fluorophenyl)acetamide

生成物 1

HCID 2773811N-(5-chloro-4-fluoro-2-nitrophenyl)acetamide

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

To a solution of N-(3-chloro-4-fluorophenyl)acetamide (55 g) in concentrated sulfuric acid (165 ml) was added dropwise concentrated nitric acid (d 1.42, 154 ml) at 5°-10° C. during an hour with stirring in an ice-salt bath. After stirring for an hour at the same temperature, the reaction mixture was poured into ice water. The resulting precipitate was collected by filtration, sufficiently washed with water and recrystallized from acetonitrile to give the title compound (48.9 g) as yellow needles, mp 114°-115° C.

後処理

  1. stirringAfter stirring for an hour at the same temperature
  2. filtrationThe resulting precipitate was collected by filtration
  3. washsufficiently washed with water
  4. customrecrystallized from acetonitrile

出典と根拠

ORDレコード
ord-9e29a83732db4959a8020002b024b850
出典データセット
uspto-grants-1989_05
特許番号
US04826982

反応ノート

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