Thionyl Chloride → 3-Bromo-2,4,5-trifluorobenzoyl chloride

HRID 1761648ノート

反応式

HRID 1761648 の反応式
[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5](O)=[O:6].S(Cl)([Cl:16])=O>>[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5]([Cl:16])=[O:6]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 27832463-Bromo-2,4,5-trifluorobenzoic acid

生成物 1

HCID 137488023-Bromo-2,4,5-trifluorobenzoyl chloride

実験手順

A solution of the 3-bromo-2,4,5-trifluorobenzoic acid (2.5 g) in thionyl chloride (10 ml) was refluxed for 2.5 hours, and then concentrated. The resulting residue was purified by distillation through Widmer fractionating column to give the title compound (2.3 g), bp 98°-102° C./18 mmHg.

後処理

  1. concentrationconcentrated
  2. distillationThe resulting residue was purified by distillation through Widmer fractionating column

出典と根拠

ORDレコード
ord-e7c2bcbdd9f2453ebd6e159b46ed4b38
出典データセット
uspto-grants-1989_05
特許番号
US04826982

反応ノート

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