Toluene → 5,7-Dimethylchroman-2-one
反応式
C(C1[C:5]([OH:17])=[CH:6][C:7]2CCCC(CCC)C=2C=1)(=O)C.C12CC3CC(CC(C3)C1=[O:28])C2.N1[CH2:33][CH2:32][CH2:31][CH2:30]1.[C:34]1([CH3:40])[CH:39]=CC=C[CH:35]=1>>[CH3:30][C:31]1[CH:35]=[C:34]([CH3:40])[CH:39]=[C:33]2[C:32]=1[CH2:7][CH2:6][C:5](=[O:17])[O:28]2参加物
5
実験手順
3-Acetyl-5-propyl-5,6,7,8-tetrahydro-2-naphthol (1) was reacted with adamantanone and pyrrolidine in toluene to give the corresponding derivative of the Example 2 compound (2) which was hydrolysed, with methanol containing a few drops of conc. hydrochloric acid, to the chromanone (3). Reduction of the chromanone (3) (2.7 g) with sodium borohydride (0.7 g) in methanol, gave the chromanol (4) (2.7 g), which was dehyrated by heating with anhydrous copper sulphate (1 g) to yield the product (5) colourless crystals from methanol (1.8 g).
出典と根拠
- ORDレコード
- ord-87cee2dc7aaa4484a65cc7844dd1961e
- 出典データセット
- uspto-grants-1989_05
- 特許番号
- US04826977
反応ノート
読み込み中…