Hydrochloric Acid → HCID 10997097、化合物
反応式
[CH2:1]([N:4]([C:9]([O:11]C)=O)[C:5](=O)[CH2:6][NH2:7])[C:2]#[CH:3].[OH-:13].[Na+].Cl>CO>[CH2:1]([N:4]1[CH2:5][C:6](=[O:13])[NH:7][C:9]1=[O:11])[C:2]#[CH:3]参加物
5
反応条件
- 温度
- 70 °C
実験手順
2.0 g of N-propargyl-N-methoxycarbonylglycinamide were added to the mixture of 5 ml of methanol and 2.5 ml of 20% aqueous solution of sodium hydroxide and maintained at 70° C. for an hour. After cooled down to room temperature; the reaction mixture was neutralized with concentrated hydrochloric acid followed by concentrating and drying the same by an evaporation under reduced pressure. Then it was extracted with acetonitrile and sodium chloride was removed off from the extract by filtration. The solvent was evaporated off from the filtrate to obtain 1.4 g of 1-propargyl-2,4-dioxoimidazolidine (melting point: 124°-125° C.).
後処理
- temperatureAfter cooled down to room temperature
- concentrationby concentrating
- customdrying the
- customsame by an evaporation under reduced pressure
- extractionThen it was extracted with acetonitrile and sodium chloride
- customwas removed off from the
- extractionextract by filtration
- customThe solvent was evaporated off from the filtrate
出典と根拠
- ORDレコード
- ord-f05c517ad5bc4a8baf1a6ee67ce0ad6f
- 出典データセット
- uspto-grants-1989_05
- 特許番号
- US04827020
反応ノート
読み込み中…