Ammonium formate → 2-Phenylbenzofuran-7-carboxylic acid

HRID 1761905

反応式

HRID 1761905 の反応式
Cl[C:2]1[CH:3]=[C:4]([C:17]([OH:19])=[O:18])[C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:7][C:6]=2[CH:16]=1.C([O-])=O.[NH4+]>CO.[C].[Pd]>[C:10]1([C:8]2[O:9][C:5]3[C:4]([C:17]([OH:19])=[O:18])=[CH:3][CH:2]=[CH:16][C:6]=3[CH:7]=2)[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 142297055-Chloro-2-phenylbenzofuran-7-carboxylic acid

生成物 1

HCID 142297062-Phenylbenzofuran-7-carboxylic acid

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

1.46 g of 5-chloro-2-phenylbenzofuran-7-carboxylic acid are dissolved in a mixture of 15 ml of ethyleneglycol monomethylethers and 15 ml of methanol. 500 mg of 10% palladium-carbon and 1.6 g of ammonium formate are added to the solution and the solution is heated at 40° C. for 1.5 hours. The reaction mixture is filtered and the filtrate is concentrated under reduced pressure. The residue is dissolved in ethyl acetate. The solution is washed successively with 10% hydrochloric acid and water, dried and evaporated to remove solvent to give 2-phenylbenzofuran-7-carboxylic acid.

後処理

  1. filtrationThe reaction mixture is filtered
  2. concentrationthe filtrate is concentrated under reduced pressure
  3. dissolutionThe residue is dissolved in ethyl acetate
  4. washThe solution is washed successively with 10% hydrochloric acid and water
  5. customdried
  6. customevaporated
  7. customto remove solvent

出典と根拠

ORDレコード
ord-b34affb6ac8946c39bb7e90c5008713e
出典データセット
uspto-grants-1989_05
特許番号
US04829067

関連ノート

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