反応式
[C:1]1([C:7]2[O:8][C:9]3[C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.O1CCCC1.[Pt]=O>[CH:1]1([C:7]2[O:8][C:9]3[C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1参加物
5
実験手順
2.5 g of 2-phenylbenzofuran-7-carboxylic acid is dissolved in a mixture of 80 ml of methanol and 16 ml of tetrahydrofuran and 0.5 g of platinum oxide is added to the solution. The mixture is subjected to catalytic hydrogenation under atmospheric pressure. The reaction mixture is filtered and the filtrate is evaporated to remove solvent. The residue is purified by silica gel column chromatography (solvent; chloroform:methanol=20:1) to give 1.54 g of 2-cyclohexylbenzofuran-7-carboxylic acid as colorless oil.
後処理
- additionis added to the solution
- filtrationThe reaction mixture is filtered
- customthe filtrate is evaporated
- customto remove solvent
- customThe residue is purified by silica gel column chromatography (solvent; chloroform:methanol=20:1)
出典と根拠
- ORDレコード
- ord-6e53bd05d1db455ca47f8363c774f39f
- 出典データセット
- uspto-grants-1989_05
- 特許番号
- US04829067
関連ノート
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