Tetrahydrofuran → Methyl 2-(4-nitrophenyl)benzofuran-7-carboxylate

HRID 1761908ノート

反応式

HRID 1761908 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]3[C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=[CH:15][C:13]=3[CH:14]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].O1CCC[CH2:23]1>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]3[C:18]([C:19]([O:21][CH3:23])=[O:20])=[CH:17][CH:16]=[CH:15][C:13]=3[CH:14]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

3

反応物 2

HCID 8028TetrahydrofuranHCID 142297282-(4-Nitrophenyl)benzofuran-7-carboxylic acid

生成物 1

HCID 14229713Methyl 2-(4-nitrophenyl)benzofuran-7-carboxylate

実験手順

A diazomethane-ether solution (prepared from 5.0 g of nitrosomethylurea) is added to a solution of 6.0 g of 2-(4-nitrophenyl)benzofuran-7-carboxylic acid in 60 ml of tetrahydrofuran and the mixture is stirred at room temperature for 1 hour. The reaction mixture is evaporated to remove solvent and the residue is dissolved in ethyl acetate. The solution is washed with water, dried and evaporated to remove solvent. The residue is washed with ethyl acetate and dried to give 3.82 g of methyl 2-(4-nitrophenyl)benzofuran-7-carboxylate as pale brown powder.

後処理

  1. customThe reaction mixture is evaporated
  2. customto remove solvent
  3. dissolutionthe residue is dissolved in ethyl acetate
  4. washThe solution is washed with water
  5. customdried
  6. customevaporated
  7. customto remove solvent
  8. washThe residue is washed with ethyl acetate
  9. customdried

出典と根拠

ORDレコード
ord-0897e720d4e74ffa9f9a8c4b94f8a771
出典データセット
uspto-grants-1989_05
特許番号
US04829067

反応ノート

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