Hydrochloric Acid → 3-Hydroxymethylchrysene

HRID 1762012

反応式

HRID 1762012 の反応式
[CH:1]1[C:18]2[CH:17]=[CH:16][C:15]3[C:6](=[CH:7][CH:8]=[C:9]4[C:14]=3[CH:13]=[CH:12][CH:11]=[CH:10]4)[C:5]=2[CH:4]=[C:3]([C:19](OCC)=[O:20])[CH:2]=1.[Li+].[BH4-].Cl>C1COCC1>[CH:1]1[C:18]2[CH:17]=[CH:16][C:15]3[C:6](=[CH:7][CH:8]=[C:9]4[C:14]=3[CH:13]=[CH:12][CH:11]=[CH:10]4)[C:5]=2[CH:4]=[C:3]([CH2:19][OH:20])[CH:2]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 4148881Lithium borohydrideHCID 15599328Ethyl chrysene-3-carboxylate2 回

生成物 1

HCID 155993273-Hydroxymethylchrysene収率 98%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of ethyl chrysene-3-carboxylate ((19E 17.7 g, 0.059 mol) in 40 mL THF was treated with LiBH4 (Morton Thiokol, Inc.-Alfa Products, PO Box 299, 152 Andover St., Danvers, MA 01923, 2.7 g, 0.12 mol) in three portions then refluxed for 3 days. The reaction mixture was poured into ice and acidified carefully to pH 1 with 1N HCl. The precipitate was filtered and recrystallized from THF/hexane to afford 14.98 g (98%) of 3-chrysenemethanol mp 187°-189°, (C,H).

後処理

  1. temperaturethen refluxed for 3 days
  2. additionThe reaction mixture was poured into ice
  3. filtrationThe precipitate was filtered
  4. customrecrystallized from THF/hexane

出典と根拠

ORDレコード
ord-18c5961ba8dc4e50b903284dd460220f
出典データセット
uspto-grants-1989_05
特許番号
US04829090

関連ノート

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