HCID 14516783、化合物 → HCID 14516793、化合物

HRID 1762039ノート

反応式

HRID 1762039 の反応式
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:15]2[S:16][CH:17]=[N:18][N:19]=2)[C:10]=1[S:11]([NH2:14])(=[O:13])=[O:12])=[O:5])[CH3:2].[CH3:20][O:21][C:22]1[CH:27]=[C:26]([O:28][CH3:29])[N:25]=[C:24]([N:30](C2C=CC=CC=2)[C:31](=O)[O-:32])[N:23]=1>C(#N)C>[CH3:29][O:28][C:26]1[CH:27]=[C:22]([O:21][CH3:20])[N:23]=[C:24]([NH:30][C:31]([NH:14][S:11]([C:10]2[N:9]([C:15]3[S:16][CH:17]=[N:18][N:19]=3)[CH:8]=[N:7][C:6]=2[C:4]([O:3][CH2:1][CH3:2])=[O:5])(=[O:13])=[O:12])=[O:32])[N:25]=1

参加物

4

反応物 2

HCID 14516783HCID 14516783、化合物HCID 22104197HCID 22104197、化合物

生成物 1

HCID 14516793HCID 14516793、化合物収率 62.6%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

0.23 g of 1,8-diazobicyclo(5,4,0)-7-undecene was added dropwise to a mixture of 0.45 g of 4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-sulfonamide, 0.41 g of N-(4,6-dimethoxypyrimidine-2-yl)phenylcarbamate and 5 ml of acetonitrile. After stirring the reaction mixture at room temperature for 20 minutes, 20 ml of ice water was added thereto and the mixture was filtered. The filtrate was made acidic with use of conc. hydrochloric acid, and resulting precipitated crystals were collected by filtration, washed with water and ethyl ether, and dried to obtain 0.45 g of the title compound. m.p.: 169° to 171° C.

後処理

  1. filtrationthe mixture was filtered
  2. customresulting
  3. customprecipitated crystals
  4. filtrationwere collected by filtration
  5. washwashed with water and ethyl ether
  6. customdried

出典と根拠

ORDレコード
ord-9c8b4f252f3041eba5b5f04d0673f3a6
出典データセット
uspto-grants-1989_05
特許番号
US04830660

反応ノート

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