Oxalyl chloride → 3-Oxazolidineacetyl chloride, 2-oxo-4,5-diphenyl-, (4S,5R)-

HRID 1762168ノート

反応式

HRID 1762168 の反応式
[C:1]1([C@H:7]2[C@@H:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[O:10][C:9](=[O:18])[N:8]2[CH2:19][C:20]([OH:22])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)(=O)C([Cl:26])=O>C1C=CC=CC=1>[C:1]1([C@H:7]2[C@@H:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[O:10][C:9](=[O:18])[N:8]2[CH2:19][C:20]([Cl:26])=[O:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 58430307[(4S,5R)-2-Oxo-4,5-diphenyl-1,3-oxazolidin-3-yl]acetic acid

生成物 1

HCID 109359773-Oxazolidineacetyl chloride, 2-oxo-4,5-diphenyl-, (4S,5R)-収率 100%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A suspension composed of (4,5-cis-diphenyl-2-oxo-3-oxazolidinyl)acetic acid (29.1 g, 97.9 mmol), oxalyl chloride (18.6 g, 147 mmol) and benzene (120 ml) was refluxed for 2 hours. When the suspension became homogeneous, the solvent was distilled off. By the above procedure there was obtained the title compound (30.9 g) as light brown oil.

後処理

  1. temperaturewas refluxed for 2 hours
  2. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-aa46dd4435d04b2cb110922d77ee3904
出典データセット
uspto-grants-1989_05
特許番号
US04831026

反応ノート

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