Water → 6-Methyl-2-methylaminobenzyl alcohol
反応式
[CH:1]([NH:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:5]=1[CH2:6][OH:7])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[CH3:12][C:8]1[C:5]([CH2:6][OH:7])=[C:4]([NH:3][CH3:1])[CH:11]=[CH:10][CH:9]=1参加物
5
実験手順
A solution of 2-formamido-6-methylbenzyl alcohol (1.9 g) in tetrahydrofuran (26 ml) was added dropwise to a suspension of lithium aluminum hydride (0.873 g) in tetrahydrofuran (17 ml) at room temperature over a period of 10 minutes. After being refluxed for 4.5 hours, the excess reagent was decomposed with a small amount of water and the resulting precipitates were filtered off by suction. The filtrate was evaporated in vacuo and the residue was recrystallized from carbon tetrachloride to give 6-methyl-2-methylaminobenzyl alcohol (0.86 g).
後処理
- temperatureAfter being refluxed for 4.5 hours
- customthe resulting precipitates
- filtrationwere filtered off by suction
- customThe filtrate was evaporated in vacuo
- customthe residue was recrystallized from carbon tetrachloride
出典と根拠
- ORDレコード
- ord-d1b51f6357394f49aaea3d7e4e62f200
- 出典データセット
- uspto-grants-1989_05
- 特許番号
- US04831041
反応ノート
読み込み中…