Ethyl Acetate → HCID 19763643、化合物

HRID 1762722ノート

反応式

HRID 1762722 の反応式
[F:1][C:2]([F:14])([F:13])[C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12])=[O:4].[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.C(OCC)(=O)C>C(Cl)Cl>[F:1][C:2]([F:13])([F:14])[C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[O:12])=[O:4]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 2724130Cornforth reagentHCID 36276076-(Trifluoroacetamido)-1-hexanol

生成物 1

HCID 19763643HCID 19763643、化合物収率 70%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
23 °C

実験手順

To 2.1 gm (10.1 mmole) of the 6-trifluroacetamido-1-hexanol in 40 ml of methylene chloride was added 3 gm (10.64 mmole) of pyridinium dichromate and 4.4 gm of 3 Angstrom molecular sieves, and the reaction was allowed to proceed with stirring for 3 hours at 23° C. After addition of 250 ml of ethyl acetate, the reaction mixture was filtered through a small bed of silica gel 60 and concentrated in vacuo. Flash chromatography using 50% (v/v) ethyl acetate in hexane afforded 1.48 gms (70%) of 6-trifluroacetamido-1-hexanal. ##STR17##

後処理

  1. filtrationthe reaction mixture was filtered through a small bed of silica gel 60
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-106ab3ab2a1448b9916eb0bd940cde3e
出典データセット
uspto-grants-1989_05
特許番号
US04833251

反応ノート

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