Chlorosulfonic acid → 4-(1-Acetylpiperidin-4-yl)benzenesulphonyl chloride

HRID 1762837ノート

反応式

HRID 1762837 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Cl:16][S:17](O)(=[O:19])=[O:18]>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([S:17]([Cl:16])(=[O:19])=[O:18])=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 11608128HCID 11608128、化合物

生成物 1

HCID 200398204-(1-Acetylpiperidin-4-yl)benzenesulphonyl chloride

実験手順

1-Acetyl-4-phenylpiperidine, [Chem. Abs., 75, 5728b (1971] (16.30 g) was added portionwise over 1 hour to stirred chlorosulphonic acid (53.3 ml) at 0°. The solution was stirred at 0° for 1 hour, then at room temperature for 2 hours, and then finally poured cautiously onto an excess of ice. When the ice had melted the mixture was extracted several times with dichloromethane. The combined organic extracts were washed with water, dried (Na2SO4) and evaporated to give the title compound, (23.0 g), m.p. 133°-134°, used directly in the next step.

後処理

  1. waitat room temperature for 2 hours
  2. additionfinally poured cautiously onto an excess of ice
  3. extractionwas extracted several times with dichloromethane
  4. washThe combined organic extracts were washed with water
  5. dry with materialdried (Na2SO4)
  6. customevaporated

出典と根拠

ORDレコード
ord-7758a8711e374a31a578e2d63a02b74d
出典データセット
uspto-grants-1989_05
特許番号
US04835165

反応ノート

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