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Chloromethyl Methyl Ether → 4-[N-benzyl-N-(2-methoxymethoxycarbonyl-1-methylethyl)aminoacetyl]-7-benzyloxyindole-2-carboxylic acid methoxymethyl ester acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloromethyl Methyl Ether | HCID 7864 | — |
| 反応物 | HOAc dioxane | HCID 22565020 | — |
| 反応物 | 4-[N-benzyl-N-(2-carboxy-1-methylethyl)aminoacetyl]-7-benzyloxyindole-2-carboxylic acid hydrochloride | HCID 70381925 | — |
| 生成物 | 4-[N-benzyl-N-(2-methoxymethoxycarbonyl-1-methylethyl)aminoacetyl]-7-benzyloxyindole-2-carboxylic acid methoxymethyl ester acetate | HCID 70381294 | — |
反応手順
Under the conditions of Example 21(A), 5 g of 4-[N-benzyl-N-(2-carboxy-1-methylethyl)aminoacetyl]-7-benzyloxyindole-2-carboxylic acid hydrochloride is reacted with 1.6 g of chloromethylmethyl ether and worked up. Treatment of the crude product with dioxane/acetic acid yields 4.2 g of 4-[N-benzyl-N-(2-methoxymethoxycarbonyl-1-methylethyl)aminoacetyl]-7-benzyloxyindole-2-carboxylic acid methoxymethyl ester acetate, decomposition point 118°-122° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04835175 |
| 出典データセット | uspto-grants-1989_05 |
| ORD ID | ord-ce23bcd3fe144526bb79bd3d3c506d84 |
| 出典メモ | uspto-grants-1989_05 |