Benzamide → Hippuric Acid
反応式
[C:1]([NH2:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].Br[CH2:13][C:14]([O-:16])=[O:15].[Na+]>CN(C)C=O>[C:14]([OH:16])(=[O:15])[CH2:13][NH:9][C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:8]参加物
5
実験手順
To 150 ml of N,N-dimethylformamide, were added 24 g of benzamide, 14 g of potassium hydroxide and 40 g of sodium bromoacetate. They were reacted at 60° C. for 4 hours with stirring. After the reaction, the reaction solution was treated in the same manner as in Example 65. The resulting distillation residue was recrystallized from distilled water, thereby obtaining 34 g of hippuric acid having a melting point of 187° C.(yield: 69%).
後処理
- customThey were reacted at 60° C. for 4 hours
- customAfter the reaction
- additionthe reaction solution was treated in the same manner as in Example 65
- distillationThe resulting distillation residue
- customwas recrystallized
- distillationfrom distilled water
出典と根拠
- ORDレコード
- ord-578c605a401849b6b0a46b9b99b9abd6
- 出典データセット
- uspto-grants-1989_05
- 特許番号
- US04835312
反応ノート
読み込み中…