Triethylamine → HCID 13233034、化合物

HRID 1763187ノート

反応式

HRID 1763187 の反応式
Cl.[C:2]([S:6][CH2:7][NH:8][CH3:9])([CH3:5])([CH3:4])[CH3:3].[F:10][C:11]([F:22])([F:21])[C:12]1[CH:13]=[C:14]([N:18]=[C:19]=[O:20])[CH:15]=[CH:16][CH:17]=1.C(N(CC)CC)C>C(#N)C>[CH3:9][N:8]([CH2:7][S:6][C:2]([CH3:5])([CH3:4])[CH3:3])[C:19]([NH:18][C:14]1[CH:15]=[CH:16][CH:17]=[C:12]([C:11]([F:10])([F:21])[F:22])[CH:13]=1)=[O:20]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 20309108N-(tert.-butylthiomethyl)-N-methyl amine hydrochloride

生成物 1

HCID 13233034HCID 13233034、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Two grams of the product of Example I (0.0118 mole), 2.2 g. (0.0118 mole) of 3-trifluoromethylphenylisocyanate, and 100 ml. of acetonitrile are combined in a 250 ml. Erlenmeyer flask. The mixture is magnetically stirred, and 1.9 g. (0.0118 mole) of triethylamine are then added. The resulting mixture is stirred at room temperature for one hour and then poured into 300 ml. of ice water. The crystalline product is collected by filtration and dried to yield 2.0 g. (53% of theory) of the title compound, mp = 96°-99° C. Structure is confirmed by IR and NMR.

後処理

  1. stirringThe resulting mixture is stirred at room temperature for one hour
  2. additionpoured into 300 ml
  3. filtrationThe crystalline product is collected by filtration
  4. customdried
  5. customto yield 2.0 g

出典と根拠

ORDレコード
ord-a6aadf5ed0a140938581a74509fa2f68
出典データセット
uspto-grants-1978_09
特許番号
US04111682

反応ノート

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