Hydrazine hydrate (1:1) → HCID 20309593、化合物

反応式

[C:1]([NH:5][CH2:6][CH:7]([OH:26])[CH2:8][O:9][C:10]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:11]=1[C:12]([CH2:14][CH2:15][C:16](OC)=[O:17])=O)([CH3:4])([CH3:3])[CH3:2].O.[NH2:28][NH2:29]>>[C:1]([NH:5][CH2:6][CH:7]([OH:26])[CH2:8][O:9][C:10]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:11]=1[C:12]1[CH2:14][CH2:15][C:16](=[O:17])[NH:28][N:29]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

反応物 2

HCID 24654Hydrazine hydrate (1:1)

HCID 20309482HCID 20309482、化合物

生成物 1

HCID 20309593HCID 20309593、化合物

実験手順

Methyl 3-[2-(3-t-butylamino-2-hydroxypropoxy)-5-methoxybenzoyl]propionate was cyclised with hydrazine hydrate in a similar manner to that described in Example 2 (ii) to give 6-[2-(3-t-butylamino-2-hydroxypropoxy)-5-methoxyphenyl]-4,5-dihydro-3(2H)-pyridazinone (m.p. 127°-128° C). The hydrochloride, crystallised from methanolether, had m.p. 227°-229° C. (Found: C, 56.24; H, 7.24; Cl, 9.06; N, 10.75; C18H27N3O4.HCl requires: C, 56.03; H, 7.31; Cl, 9.19; N, 10.88%)

出典と根拠

ORDレコード: ord-8a6bec05c5a941488542fab8259d5944
出典データセット: uspto-grants-1978_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04111936

反応ノート

読み込み中…

参加物