3,4-Dichlorobenzyl chloride → 4-Methyl-1-(3,4-dichlorobenzyl)-pyrazol-5-one
反応式
[CH3:1][C:2]1[C:6](=[O:7])[N:5]=[N:4][CH:3]=1.[H-].[Na+].[Cl:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[Cl:19])[CH2:14]Cl>CN(C)C=O>[CH3:1][C:2]1[C:6](=[O:7])[N:5]([CH2:14][C:13]2[CH:16]=[CH:17][C:18]([Cl:19])=[C:11]([Cl:10])[CH:12]=2)[NH:4][CH:3]=1参加物
5
実験手順
19.6 g of 4-methylpyrazol-5-one were added in portions to a suspension of 5.0 g of sodium hydride in 100 ml of absolute dimethylformamide. After the evolution of H2 had ceased, 39 g of 3,4-dichlorobenzyl chloride were added dropwise to the reaction solution.
出典と根拠
- ORDレコード
- ord-a61cf8c427de4cf49d7414033ea29685
- 出典データセット
- uspto-grants-1978_09
- 特許番号
- US04112227
反応ノート
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