HCID 178465162、化合物 → HCID 178465164、化合物
反応式
[ClH:1].[CH2:2]([NH:4][C:5](=[O:40])[C@@H:6]1[CH2:10][CH2:9][CH2:8][N:7]1[C:11](=[O:39])[C@H:12]([CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:38])[NH2:37])[NH:13][C:14](=[O:31])[C@H:15]([CH2:27][CH:28]([CH3:30])[CH3:29])[NH:16]C(OCC1C=CC=CC=1)=O)[CH3:3]>[Pd].CO>[ClH:1].[CH2:2]([NH:4][C:5](=[O:40])[C@@H:6]1[CH2:10][CH2:9][CH2:8][N:7]1[C:11](=[O:39])[C@H:12]([CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:37])[NH2:38])[NH:13][C:14](=[O:31])[C@H:15]([CH2:27][CH:28]([CH3:29])[CH3:30])[NH2:16])[CH3:3]参加物
4
実験手順
To a solution of 1.8 g. of Nα -benzyloxycarbonyl-L-leucyl-L-arginyl-L-proline-N-ethylamide hydrochloride in 100 ml. of methanol is added 400 mg. of 20% palladium on carbon and the mixture is stirred under a hydrogen atmosphere for four hours. Disappearance of the starting material is determined by thin layer chromatography of samples of the solution. The catalyst is removed by filtration and the filtrate is evaporated to dryness. The product is used without further purification.