2-Methylbenzenesulfonic acid → HCID 20307437、化合物

HRID 1763778ノート

反応式

HRID 1763778 の反応式
[CH2:1]([N:4]([CH2:9][CH:10]([O:13][CH3:14])[O:11][CH3:12])[C:5](=[O:8])[CH2:6][Cl:7])[C:2]#[CH:3].C1(C)C(S(O)(=O)=O)=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH2:1]([N:4]([CH2:9][CH:10]1[O:11][CH2:12][CH2:14][O:13]1)[C:5](=[O:8])[CH2:6][Cl:7])[C:2]#[CH:3]

参加物

5

反応物 3

HCID 69252-Methylbenzenesulfonic acidHCID 10340Sodium CarbonateHCID 20307409HCID 20307409、化合物

生成物 1

HCID 20307437HCID 20307437、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

N-Propargyl-N-(2,2-dimethoxyethyl)-α-chloroacetamide (8.5 grams), ethandiol-1,2 (2.16 ml) and trace amounts of toluenesulfonic acid were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated at reflux until no more ethanol was given off. After this time sodium carbonate (1 gram) was added to the mixture with stirring and the resulting mixture was distilled to yield the desired product N-propargyl-N-(1,3-dioxolan-2-ylmethyl)-α-chloroacetamide having a boiling point of 160° to 165° C. at 1 mm of Hg pressure.

後処理

  1. additionwere charged into a glass reaction vessel
  2. customequipped with a mechanical stirrer
  3. temperaturethermometer and reflux condenser
  4. temperatureThe reaction mixture was heated
  5. distillationthe resulting mixture was distilled

出典と根拠

ORDレコード
ord-9a5c7a12461a462ca56932389872f23b
出典データセット
uspto-grants-1978_09
特許番号
US04113464

反応ノート

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