Sodium Hydroxide → HCID 20307400、化合物

HRID 1763784

反応式

HRID 1763784 の反応式
Br[CH2:2][CH:3]=[O:4].[CH3:5][CH:6]([NH2:12])[CH2:7][CH2:8][CH:9]([CH3:11])[CH3:10].[OH-].[Na+]>O>[CH3:5][CH:6]([NH:12][CH2:2][CH:3]=[O:4])[CH2:7][CH2:8][CH:9]([CH3:11])[CH3:10]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 342045-Methyl-2-hexylamineHCID 105131Acetaldehyde, bromo-

生成物 1

HCID 20307400HCID 20307400、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

The diethylacetal of 2-bromoacetaldehyde (40 grams) and 1,4-dimethylpentylamine (50 grams) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated at a temperature of about 100° C. for a period of about 3 hours. After this time sodium hydroxide (10 grams) dissolved in water (100 ml) was added and the resulting mixture stirred for about 30 minutes. The reaction mixture was then extracted with ether. The ether extract was separated, dried over magnesium sulfate, filtered and stripped of solvent under reduced pressure to yield the desired product the diethylacetal of 2-(1,4-dimethylpentylamino)acetaldehyde having a boiling point of 95° C. at 1 mm of Hg pressure.

後処理

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. additionwas added
  4. extractionThe reaction mixture was then extracted with ether
  5. extractionThe ether extract
  6. customwas separated
  7. dry with materialdried over magnesium sulfate
  8. filtrationfiltered

出典と根拠

ORDレコード
ord-dd0ee538c13e454d8bc039c1439d89ca
出典データセット
uspto-grants-1978_09
特許番号
US04113464

関連ノート

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