Sodium Hydroxide → HCID 20307430、化合物

反応式

Br[CH2:2][CH:3]1[O:7][CH:6]([CH3:8])[CH:5]([CH3:9])[O:4]1.[CH3:10][C:11]([NH2:15])([CH3:14])[C:12]#[CH:13].[OH-].[Na+]>O>[CH3:10][C:11]([NH:15][CH2:2][CH:3]1[O:7][CH:6]([CH3:8])[CH:5]([CH3:9])[O:4]1)([CH3:14])[C:12]#[CH:13]

参加物

反応条件

温度: 100 °C

実験手順

2-Bromomethyl-4,5-dimethyl-1,3-dioxolane (20 grams) and 1,1-dimethylprop-2-ynylamine (100 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at a temperature of about 100° C. for a period of about 3 hours. After this time sodium hydroxide (10 grams) dissolved in water (100 ml) is added and the resulting mixture is stirred for a period of about 30 minutes. The reaction mixture is then extracted with ether. The ether extract is dried over anhydrous magnesium sulfate, filtered and stripped of solvent to yield the desired product N-(1,1-dimethylprop-2-ynyl)-N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)amine.