3-Chlorophthalide → Phthalide
反応式
Cl[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[O:3]1.C([O-])(=O)C.[Na+].[H][H]>[Pd].C(O)(=O)C>[C:4]1([C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:2][O:3]1)=[O:5]参加物
6
実験手順
As described in Example 1, an autoclave is charged with 110 g of 3-chlorophthalide, 5 g of palladium-on-charcoal catalyst (metal content 5%), 54 g of sodium acetate and 400 ml of glacial acetic acid, and treated for 1.5 h with hydrogen at 5 to 10 bars of pressure and 20° to 35° C. After filtration and working up by distillation, 76.5 g of phthalide is obtained, melting point 72°-73° C. (gas-chromatographic analysis 99.35).
後処理
- filtrationAfter filtration
- distillationworking up by distillation
出典と根拠
- ORDレコード
- ord-ba1572a198a44933b7ac9b2331c2dc4c
- 出典データセット
- uspto-grants-1978_09
- 特許番号
- US04113741
反応ノート
読み込み中…