6-Methyluracil → 5-Fluoro-6-methylpyrimidine-2,4-diol

HRID 1763947ノート

反応式

HRID 1763947 の反応式
[CH3:1][C:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=[O:9])[CH:3]=1.[F:10]F>O>[F:10][C:3]1[C:4](=[O:9])[NH:5][C:6](=[O:8])[NH:7][C:2]=1[CH3:1]

参加物

4

反応物 2

HCID 122836-MethyluracilHCID 24524Fluorine2 回

生成物 1

HCID 2338935-Fluoro-6-methylpyrimidine-2,4-diol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The preceding example was substantially repeated but at a lower reaction temperature. A suspension of 6-methyl uracil (4.00 g) in water (30 ml) was maintained at 0°-10° C. and fluorinated with a stream of fluorine and nitrogen, present in equal volumes, until fluorine was detected at the reactor outlet. The reaction mixture was allowed to stand for two days at room temperature and 1.05 g of crystals were collected and found to have a different IR spectrum than the starting material. A DSC analysis showed 2 transitions at 313° C. and 318° C. followed by apparent decomposition. The structure of the product was identified as 5-fluoro-6-methyl uracil by NMR analysis.

後処理

  1. temperaturewas maintained at 0°-10° C.
  2. custom1.05 g of crystals were collected
  3. customat 313° C.
  4. custom318° C.

出典と根拠

ORDレコード
ord-b41060b5f54b4cd594ddfc40259e85e8
出典データセット
uspto-grants-1978_09
特許番号
US04113949

反応ノート

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