1-Methylpiperazine → HCID 47864、化合物

HRID 1763952ノート

反応式

HRID 1763952 の反応式
[C:1]([NH:4][C:5]1[C:6]([O:18][CH2:19][CH2:20]Cl)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>C1(C)C=CC=CC=1>[C:1]([NH:4][C:5]1[C:6]([O:18][CH2:19][CH2:20][N:26]2[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]2)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 531671-MethylpiperazineHCID 12672371HCID 12672371、化合物

生成物 1

HCID 47864HCID 47864、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 15.5 g (0.05 mole) of 5-acetamido 6-(2-chloro ethoxy) 4,7 dimethoxy benzofuran prepared in the preceding example and 15 g (0.15 mole) of N-methyl piperazine was brought to reflux for 8 hours in 100 ml of toluene. It was filtered and the filtrate evaporated under vacum the residue was taken up again in alcohol and hydrochloric alcohol was added. It was filtered and recrystallized in absolute alcohol.

後処理

  1. filtrationIt was filtered
  2. customthe filtrate evaporated under vacum the residue
  3. additionhydrochloric alcohol was added
  4. filtrationIt was filtered
  5. customrecrystallized in absolute alcohol

出典と根拠

ORDレコード
ord-73ae93da663f4046b3e7c6e1692248ec
出典データセット
uspto-grants-1978_09
特許番号
US04113951

反応ノート

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