Methanol → 4H-Pyran-3-carboxylic acid, 2,6-dimethyl-4-oxo-, methyl ester
反応式
[C:1]([C:4]1[C:9](=[O:10])[CH:8]=[C:7]([CH3:11])[O:6][C:5]=1[CH3:12])([OH:3])=[O:2].[C:13](Cl)(=O)C.CO.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)Cl>[C:1]([C:4]1[C:9](=[O:10])[CH:8]=[C:7]([CH3:11])[O:6][C:5]=1[CH3:12])([O:3][CH3:13])=[O:2]参加物
6
実験手順
42 g of 3-carboxy-2,6-dimethylpyr-4-one is dissolved in 250 ml of methylene chloride. In a second flask, 20 ml of acetyl chloride is cautiously added to 400 ml of methanol. The two solutions are mixed and refluxed for 5 hours. Solid sodium carbonate is added and the solvent removed after a water wash. The residue is distilled (115°-125° at 0.1 mm) to give 40 g of 3-carbomethoxy-2,6-dimethylpyr-4-one as a waxy solid.
後処理
- additionThe two solutions are mixed
- temperaturerefluxed for 5 hours
- customthe solvent removed after a water
- washwash
- distillationThe residue is distilled (115°-125° at 0.1 mm)
出典と根拠
- ORDレコード
- ord-129f2194fb3845afae7f67a2d6263e74
- 出典データセット
- uspto-grants-1978_09
- 特許番号
- US04115101
反応ノート
読み込み中…