Sodium Hydroxide → alpha-[p-(1-Cyclohexenyl)-phenoxy]-dodecanoic acid

HRID 1764138ノート

反応式

HRID 1764138 の反応式
C([O:3][C:4](=[O:29])[CH:5]([O:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH:24]=2)=[CH:19][CH:18]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])C.[OH-].[Na+]>C(O)C>[C:23]1([C:20]2[CH:19]=[CH:18][C:17]([O:16][CH:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:4]([OH:29])=[O:3])=[CH:22][CH:21]=2)[CH2:28][CH2:27][CH2:26][CH2:25][CH:24]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 54458993alpha-[p-(1-Cyclohexenyl)-phenoxy]-dodecanoic acid ethyl ester

生成物 1

HCID 20306768alpha-[p-(1-Cyclohexenyl)-phenoxy]-dodecanoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

To 23.5gof α-[p-(1-cyclohexenyl)-phenoxy]-dodecanoic acid ethyl ester in 150 ml of ethanol are added 100 ml of 2N sodium hydroxide solution and the mixture stirred for 2 hours at room temperature. The ethanol is stripped off in vacuo and the residue partitioned between 2N hydrochloric acid and ether. The organic phase is washed until neutral, dried over sodium sulphate and evaporated to dryness. Distillation of the residue at 0.04 mm yields in the fraction boiling at 190°-197° C the α-[p-(1-cyclohexenyl)-phenoxy]-dodecanoic acid of the formula ##STR18## (m.p. 70°-72° C).

後処理

  1. customthe residue partitioned between 2N hydrochloric acid and ether
  2. washThe organic phase is washed until neutral,
  3. dry with materialdried over sodium sulphate
  4. customevaporated to dryness
  5. distillationDistillation of the residue at 0.04 mm

出典と根拠

ORDレコード
ord-a2606d5581ba4beba9c40eb0a5071c19
出典データセット
uspto-grants-1978_09
特許番号
US04115416

反応ノート

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