O-Phenylenediamine → 4-(2-Aminoanilino)-2,5-dihydrothiophene-3-carbonitrile

HRID 1764251ノート

反応式

HRID 1764251 の反応式
O=[C:2]1[CH:6]([C:7]#[N:8])[CH2:5][S:4][CH2:3]1.[C:9]1([NH2:16])[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH2:15]>C(O)(=O)C>[NH2:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[NH:16][C:2]1[CH2:3][S:4][CH2:5][C:6]=1[C:7]#[N:8]

参加物

4

反応物 2

HCID 7243O-PhenylenediamineHCID 3266764-Oxothiolane-3-carbonitrile

生成物 1

HCID 203877024-(2-Aminoanilino)-2,5-dihydrothiophene-3-carbonitrile

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

3-Keto-4-cyanotetrahydrothiophene (80 g, 0.629 mol) and o-phenylenediamine (68 g, 0.629 mol) were dissolved by heating in 1.5 litres of industrial methylated spirit. To the solution, glacial acetic acid (3 ml) was added, the solution then being heated under reflux with mechanical stirring for 24 hours. The solution was then chilled and filtered to give the title product as a solid, m.p. 163° C.

後処理

  1. temperaturethe solution then being heated
  2. temperatureunder reflux
  3. temperatureThe solution was then chilled
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-b47d6d96eb4c4ecca3572f4ea27dd5df
出典データセット
uspto-grants-1978_09
特許番号
US04115568

反応ノート

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