Ethyl Acetate → 4-(2-Amino-4-chloroanilino)thiophene-3-carbonitrile

HRID 1764252ノート

反応式

HRID 1764252 の反応式
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([NH:6][C:7]2[C:11]([C:12]#[N:13])=[CH:10][S:9][CH:8]=2)=[C:4]([N+:16]([O-])=O)[CH:3]=1.C(OCC)(=O)C>C(O)C.[Pd]>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([NH:6][C:7]2[C:11]([C:12]#[N:13])=[CH:10][S:9][CH:8]=2)=[C:4]([NH2:16])[CH:3]=1

参加物

5

反応物 2

HCID 8857Ethyl AcetateHCID 12658710HCID 12658710、化合物

生成物 1

HCID 203877584-(2-Amino-4-chloroanilino)thiophene-3-carbonitrile

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

3-(4-Chloro-2-nitroanilino)-thiophene-4-nitrile (17.18 g, 0.06 mol) was hydrogenated in ethanol (300 ml) and ethyl acetate (100 ml) using a palladium/charcoal catalyst (3.5 g, 10%) in a Parr hydrogenator to give 3-(4-Chloro-2-aminoanilino)-thiophene-4-nitrile. After two hours, the reaction was complete, the catalyst was filtered off and the solution was evaporated to dryness under vacuum.

出典と根拠

ORDレコード
ord-944397517ab74cf895419a8977e25e60
出典データセット
uspto-grants-1978_09
特許番号
US04115568

反応ノート

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