Sodium Hydroxide → Aluminium alpha-[4-(1-oxo-4,7-dihydro-2-isoindolinyl)phenyl]propionate

HRID 1764498

反応式

HRID 1764498 の反応式
[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([OH:20])=[O:19])=[CH:13][CH:12]=1.[OH-].[Na+].O.O.O.O.O.O.[Cl-].[Al+3:31].[Cl-].[Cl-]>O>[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([O-:20])=[O:19])=[CH:13][CH:12]=1.[Al+3:31].[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([O-:20])=[O:19])=[CH:13][CH:12]=1.[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([O-:20])=[O:19])=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 3047153Benzeneacetic acid, alpha-methyl-4-(1,3,4,7-tetrahydro-1-oxo-2H-isoindol-2-yl)-HCID 9794789AlCl3.6H2O

生成物 1

HCID 22768525Aluminium alpha-[4-(1-oxo-4,7-dihydro-2-isoindolinyl)phenyl]propionate収率 85.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of 0.5 g (0.0018 mole) of α-[4-(1-oxo-4,7-dihydro-2-isoindolinyl)phenyl]propionic acid, 0.072 g (0.0018 mole) of sodium hydroxide and 5 ml of water was stirred for about 1 hour. At the end of this time, a solution of 0.434 g (0.0018 mole) of aluminium chloride hexahydrate in 10 ml of water was added dropwise at room temperature to the mixture. The white precipitate produced was collected by filtration, washed with 75 ml of water and dried at 105° C. for 4 hours. There was obtained 0.45 g of a white solid, which was sparingly soluble in most organic solvents and slightly soluble in dimethyl sulphoxide, and which had a melting point over 300° C.

後処理

  1. customThe white precipitate produced
  2. filtrationwas collected by filtration
  3. washwashed with 75 ml of water
  4. customdried at 105° C. for 4 hours

出典と根拠

ORDレコード
ord-71f90a0b857a46e498678bb79a5dbba5
出典データセット
uspto-grants-1978_09
特許番号
US04116972

関連ノート

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