Methanol → 2-n-Butyl-3-[4-(2-diethylaminoethoxy)phenylsulfonyl]benzofuran

To a solution of 1.4 g. (0.0042 mol.) of 2-n-butyl-3-(4-hydroxyphenylsulfonyl)benzofuran in 20 ml. of methanol was added 25 ml. of methanol containing 110 mg. (0.0048 g.-atom) of sodium. The reaction mixture was heated on a steam bath for 30 minutes then evaporated to dryness. The residue was dissolved in 25 ml. of toluene and ca. 1 ml. of methanol, a suspension of 0.615 g. (0.0048 mol.) of distilled 2-diethylaminoethyl chloride in 15 ml. of toluene was added and the resulting mixture was heated on a steam bath for 3 hours. The solution was filtered through MgSO4 and chromatographed on silica gel with 50:50 ether-acetone to give the title compound.

1. temperatureThe reaction mixture was heated on a steam bath for 30 minutes
2. customthen evaporated to dryness
3. dissolutionThe residue was dissolved in 25 ml
4. additionof methanol, a suspension of 0.615 g
5. temperaturethe resulting mixture was heated on a steam bath for 3 hours
6. filtrationThe solution was filtered through MgSO4
7. customchromatographed on silica gel with 50:50 ether-acetone

ORDレコード

ord-d5d99ab4c1214e81b2f3b03e5f627bff

出典データセット

uspto-grants-1978_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04117128