Acetone Cyanohydrin → HCID 54523296、化合物

HRID 1764719

反応式

HRID 1764719 の反応式
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]2[CH2:8][CH2:9][CH:10]=[CH:11][C:12](=[O:13])[C:6]=2[CH:5]=1)([O-:3])=[O:2].CC(C)(O)[C:18]#[N:19]>>[N+:1]([C:4]1[CH:15]=[CH:14][C:7]2[CH2:8][CH2:9][CH:10]([C:18]#[N:19])[CH2:11][C:12](=[O:13])[C:6]=2[CH:5]=1)([O-:3])=[O:2]

参加物

3

反応物 2

HCID 6406Acetone CyanohydrinHCID 200947328,9-dihydro-3-nitro-5H-benzocyclohepten-5-one

生成物 1

HCID 54523296HCID 54523296、化合物

実験手順

The novel process of the invention for the preparation of a compound of formula I wherein X is nitro comprises reacting 3-nitro-8,9-dihydro [5H] benzocycloheptene-5-one of the formula ##STR3## with acetone cyanhydrin of the formula to obtain 3-nitro-5-oxo-6,7,8,9-tetrahydro [5H] benzocycloheptene-7-carbonitrile of the formula ##STR4## reducing the latter with diborane in an organic solvent to obtain 3-nitro-7-aminomethyl-6,7,8,9-tetrahydro [5H] benzocycloheptene-5-ol of the formula ##STR5## deshydrating the latter to form 2-nitro-6,7-dihydro [5H] benzocycloheptene-7-methanamine of the formula ##STR6## and either reacting the latter with formic aldehyde and sodium cyanoborohydride to obtain N,N-dimethyl-2-nitro-6,7-dihydro [5H] benzocycloheptene 7-methanamine of the formula ##STR7## which may be reacted with an alkyl chloroformate of the formula

後処理

  1. customThe novel process of the invention for the preparation of a compound of formula I wherein X

出典と根拠

ORDレコード
ord-5f28c8fa63124e45bd3c38950184f27f
出典データセット
uspto-grants-1978_09
特許番号
US04117164

関連ノート

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