Butylamine → N-butyl-5-fluoro-2-nitroaniline

To a stirred solution of 2,4-difluoronitrobenzene (50 mmol), Et3N (100 mmol) and DMF (80 mL) was added dropwise a solution of n-butylamine (51 mmol) in DMF (20 mL) at rt, and the mixture was stirred at rt for 5 h. The reaction was quenched by cold H2O (100 mL), and the resulting mixture was extracted with EtOAc (4×100 mL). The combined EtOAc extracts were washed with brine (3×60 mL) and dried (anhydrous Na2SO4). The solvent was removed in vacuo to afford the desired 2-n-butylamino-4-fluoronitrobenzene which was used for further transformation.

1. customThe reaction was quenched by cold H2O (100 mL)
2. extractionthe resulting mixture was extracted with EtOAc (4×100 mL)
3. washThe combined EtOAc extracts were washed with brine (3×60 mL)
4. dry with materialdried (anhydrous Na2SO4)
5. customThe solvent was removed in vacuo

ORDレコード

ord-c062db97d9534d338977671ba9c26a1b

出典データセット

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07737285B2