Butylamine → N-butyl-5-fluoro-2-nitroaniline
反応式
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].CCN(CC)CC.[CH2:19]([NH2:23])[CH2:20][CH2:21][CH3:22]>CN(C=O)C>[CH2:19]([NH:23][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10])[CH2:20][CH2:21][CH3:22]参加物
5
実験手順
To a stirred solution of 2,4-difluoronitrobenzene (50 mmol), Et3N (100 mmol) and DMF (80 mL) was added dropwise a solution of n-butylamine (51 mmol) in DMF (20 mL) at rt, and the mixture was stirred at rt for 5 h. The reaction was quenched by cold H2O (100 mL), and the resulting mixture was extracted with EtOAc (4×100 mL). The combined EtOAc extracts were washed with brine (3×60 mL) and dried (anhydrous Na2SO4). The solvent was removed in vacuo to afford the desired 2-n-butylamino-4-fluoronitrobenzene which was used for further transformation.
後処理
- customThe reaction was quenched by cold H2O (100 mL)
- extractionthe resulting mixture was extracted with EtOAc (4×100 mL)
- washThe combined EtOAc extracts were washed with brine (3×60 mL)
- dry with materialdried (anhydrous Na2SO4)
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-c062db97d9534d338977671ba9c26a1b
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07737285B2
反応ノート
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