Methyl iodide → HCID 22477336、化合物

反応式

[CH3:1][N:2]([CH3:19])[CH2:3][C:4]1[C:12]2[C:7](=[N:8][CH:9]=[CH:10][N:11]=2)[NH:6][C:5]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[I:20][CH3:21]>C(OCC)(=O)C.C(O)C>[I-:20].[CH3:1][N+:2]([CH3:21])([CH3:19])[CH2:3][C:4]1[C:12]2[C:7](=[N:8][CH:9]=[CH:10][N:11]=2)[NH:6][C:5]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

反応条件

温度: 0 °C

実験手順

A solution of dimethyl-(6-phenyl-5H-pyrrolo[2,3-b]pyrazin-7-ylmethyl)-amine [5.1 g, Reference Example 32] in ethyl acetate (100 mL) at 0° C. was treated with a solution of iodomethane (40 mL) in ethanol (150 mL). The resulting mixture was stirred at 0° C. for 2 hours. The precipitated solid was filtered then washed with ethyl acetate (10 mL) and then with diethyl ether (20 mL) to give the title compound as a yellow solid (4.5 g), m.p. 224–225° C.