tert-butyl(2S)-2-((3S)-3-{[(benzyloxy)carbonyl]amino}-2-oxopyrrolidin-1-yl)propanoate → tert-Butyl(2S)-2-[(3S)-3-amino-2-oxopyrrolidin-1-yl)propanoate

HRID 1765622ノート

反応式

HRID 1765622 の反応式
C(OC([NH:11][C@H:12]1[CH2:16][CH2:15][N:14]([C@@H:17]([CH3:25])[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[C:13]1=[O:26])=O)C1C=CC=CC=1>[Pd].C(O)C>[NH2:11][C@H:12]1[CH2:16][CH2:15][N:14]([C@@H:17]([CH3:25])[C:18]([O:20][C:21]([CH3:23])([CH3:22])[CH3:24])=[O:19])[C:13]1=[O:26]

参加物

4

反応物 1

HCID 16124826tert-butyl(2S)-2-((3S)-3-{[(benzyloxy)carbonyl]amino}-2-oxopyrrolidin-1-yl)propanoate

生成物 1

HCID 69222344tert-Butyl(2S)-2-[(3S)-3-amino-2-oxopyrrolidin-1-yl)propanoate収率 101.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of tert-butyl (2S)-2-((3S)-3-{[(benzyloxy)carbonyl]amino}-2-oxopyrrolidin-1-yl)propanoate (2.82 g), 10% palladium on carbon (0.3 g) and ethanol (150 ml) was stirred under an atmosphere of hydrogen for 18 h. The reaction mixture was filtered through Harbolite™ and the filtrate was concentrated under reduced pressure to give the title compound (1.8 g) as a pale yellow oil.

後処理

  1. filtrationThe reaction mixture was filtered through Harbolite™
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-fedac5f4c05d46768e9728ef667632bb
出典データセット
uspto-grants-2007_06
特許番号
US07226929B2

反応ノート

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