Ammonia → N-(piperidin-3-yl)benzamide

HRID 1765633

反応式

HRID 1765633 の反応式
[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O.N>C(Cl)Cl>[NH:12]1[CH2:13][CH2:14][CH2:15][CH:10]([NH:9][C:1](=[O:8])[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:11]1

参加物

5

反応物 3

HCID 222AmmoniaHCID 6422Trifluoroacetic acidHCID 22017033tert-Butyl 3-(benzoylamino)piperidine-1-carboxylate

生成物 1

HCID 22017045N-(piperidin-3-yl)benzamide収率 105.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of tert-butyl 3-(benzoylamino)piperidine-1-carboxylate (0.120 g) in DCM (5 ml) was treated with trifluoroacetic acid (5 ml) and stirred at room temperature for 6 h. The mixture was concentrated under reduced pressure to give a yellow oil which following neutralisation with aqueous ammonia solution, was purified using SPE (silica, eluting with methanol and 5% aqueous ammonia in methanol) to give the title compound (0.085 g) as an off-white solid.

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customto give a yellow oil which
  3. customwas purified
  4. washSPE (silica, eluting with methanol and 5% aqueous ammonia in methanol)

出典と根拠

ORDレコード
ord-97222fd419b241aaa580612039b85ce0
出典データセット
uspto-grants-2007_06
特許番号
US07226929B2

関連ノート

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