N,N-diethyl-N-[3-(3-nitrophenoxy)propyl]amine → N-[3-(3-aminophenoxy)propyl]-N,N-diethylamine

HRID 17659

反応式

HRID 17659 の反応式
[CH2:1]([N:3]([CH2:17][CH3:18])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-])=O)[CH:9]=1)[CH3:2]>CO.[Pd]>[NH2:14][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=1)[O:7][CH2:6][CH2:5][CH2:4][N:3]([CH2:1][CH3:2])[CH2:17][CH3:18]

参加物

4

反応物 1

HCID 22012884N,N-diethyl-N-[3-(3-nitrophenoxy)propyl]amine

生成物 1

HCID 28300924N-[3-(3-aminophenoxy)propyl]-N,N-diethylamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

The N,N-diethyl-N-[3-(3-nitrophenoxy)propyl]amine (1 mmol) was dissolved in MeOH (5 mL) and hydrogenated in the presence of 10% Pd/C (50 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired N-[3-(3-aminophenoxy)propyl]-N,N-diethylamine, which was used directly for further transformation without further purification.

後処理

  1. filtrationThe reaction mixture was then filtered
  2. customto remove the catalyst
  3. customThe solvent was removed in vacuuo

出典と根拠

ORDレコード
ord-7a0fcccdeb344ea994fe2adf34712ddf
出典データセット
uspto-grants-2010_06
特許番号
US07737285B2

関連ノート

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